Annual zoledronic acid infusion lowers risk of fracture, death ncbi. Zoledronic acid versus risedronate zoledronic acid a single 5 mg infusion was. Zoledronate infusion subsidy scheme zoledronate administration protocol zoledronate infusion protocol date updated. Also, my rheumatologist told me to be diligent at taking my calcium and vit d. Zoledronic acid reclast zoledronic acid is a bisphosphonate prescribed to prevent or treat osteoporosis or pagets disease. It is available as a generic, but you have to see a doctor to get each dose. Prior authorization protocol reclast zoledronic acid. Patient will be monitored for an appropriate length of time post. I am taking nexium daily, which has relieved my gi symptoms. Sep 01, 2019 reclast is given as an infusion into a vein by a nurse or a doctor, and the infusion time must not be less than 15 minutes. Zoledronic acid is indicated for the prevention of skeletalrelated events sres such as pathological fractures, bone pain, spinal compression, need for bone radiation, or surgery in patients with bone metastases, at a recommended dose of 4 mg iv every 34 weeks, and for the treatment of hypercalcemia of malignancy hcm at a recommended dose. She tried taking an oral bisphosphonate but couldnt tolerate the gastrointestinal side effects. Unlike other common bisphosphonates that are taken by mouth, reclast bypasses the stomach because it is an infusion into the bloodstream. Reclast side effects include any and all of the other problems of osteoporosis drugs, including osteonecrosis of the jaw and nontraumatic fractures, but because reclast is given as a once yearly intravenous infusion, it can cause some unique side effects that can only occur when drugs are given via an intravenous dosage like the reclast infusion is.
Prior authorization protocol reclast zoledronic acid natl. This will help reduce possible side effects, which are most. Highlights of prescribing information hypocalcemia may. The optimal duration of use has not been determined.
Topical, as needed, pre proceduretreatment, apply prior to the piv insertion or port access, starting s. Ensure appropriate hydration, especially in patients on diuretics. Dear cardjen, i had the same problems as you described with oral meds. The reclast infusion time must not be less than 15 minutes given over a constant infusion rate. Osteoporosis is a disease which causes bones to become thin. I had, and continue to have, no side effects that i notice from the infusion. Calcium 1,500mg daily in divided doses for 2 weeks after receiving reclast lidocaine 1% up to 0. Reclast injection is available as a sterile solution in bottles for intravenous infusion.
Reclast reclast contains the same active ingredient found in zometa. Reclast zoledronic acid is a bisphosphonate used to treat pagets disease, high blood levels of calcium caused by cancer hypercalcemia of malignancy, multiple myeloma a type of bone marrow cancer or cancer that has spread from elsewhere in the body to the bone, to treat or prevent osteoporosis in postmenopausal women, and to increase bone mass in men with osteoporosis. Reclast5 mg yearly zometa standard premedications will be administered according to pi unless otherwise speci. Aclasta zoledronic acid 5 mg100 ml solution for infusion. Infusion of solution must be completed within 24 hours of initial reconstitution. The reclast patient assistance program provides assistance to patients experiencing financial hardship who have no thirdparty insurance coverage for their medicines. Checking in after my reclast iv infusion osteoporosis inspire. The safety and efficacy of reclast for the treatment of osteoporosis is based on clinical data of three years duration. Being prepared and knowing what to expect can help you feel comfortable with the infusion experience. The infusion time must not be less than 15 minutes given over a constant infusion rate.
The maximum recommended zoledronic acid dose for the treatment of bone metastases is 4 mg by iv infusion, infused over no. Postdose symptoms decreased in frequency in the zoledronic acid group after the second and third infusion 6. Patients must receive adequate hydration prior to the administration of reclast. I held my am diuretic pill until after the infusion. He is recommending reclast infusion once a year for i think three years and then none. Patient must not have prescription drug coverage public or private.
Reclast zoledronic acid is a prescription drug used to treat osteoporosis in men, postmenopausal women, and pagets disease. Reclast fda prescribing information, side effects and uses. May 08, 2020 the ph of the reclast solution for infusion is approximately 6. The infusion protocol for zoledronic acid is briefly outlined in table 1. Reclast zoledronic acid dose, indications, adverse effects.
Prior to each dose, obtain serum creatinine and calculate the. Side effects of reclast zoledronic acid injection, warnings. Reclast zoledronic acid is an expensive drug used to treat pagets disease and osteoporosis in women. Reclast solution for infusion must not be allowed to come in contact with any calcium or other divalent cationcontaining solutions, and should be. Then after the infusion i came home and drank tea, decaf, water, and juice all day. Current evidence suggests that a dosing interval of 1. There are currently no generic alternatives to reclast. This emedtv page lists other medicines that can interact with reclast, describes the problems they can cause, and explains how they can be avoided. Reclast infusion instructions vanderbilt university medical. What treatment can you recommend to reduce her risk of sustaining. The day after the infusion i felt slightly tired and achey for 1 day. Zoledronic acid, in combination with calcium and vitamin d, will reduce the risk of. If you have questions about the process, we may have the answers. It is also used to treat a cancer called multiple myeloma tumors formed by the cells of the bone marrow or certain types of bone metastases the spread of cancer to the bone.
All patients should take 1,500 mg elemental calcium daily in divided doses 750 mg twice daily or 500 mg 3 times daily and 800 international units vitamin d per day, particularly in the 2 weeks following a dose. I gather they dont want the drug to sit on your kidneys. You should drink 2 glasses of fluid at least one hour before receiving your infusion. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and. These include osteoporosis, high blood calcium due to cancer, bone breakdown due to cancer, and pagets disease of bone.
A patient that is already receiving zometa should not be treated with reclast. Zoledronic acid reclast order form infusion solutions. On the day of treatment the patient should eat and drink normally, which includes drinking at least 2 glasses of fluid such as water within a few hours prior to the infusion, as directed by their doctor, before receiving. Only clear solution, free from particles and discoloration, should be used. Zoledronic acid, also known as zoledronate, is a medication used to treat a number of bone diseases.
How to prepare for 1st reclast infusion dailystrength. Reclast infusion instructions 2 weeks prior to infusion and 2 weeks after infusion 1 increase daily calcium to 1500 mg 2 take at least 2,000 iu of vitamin d daily 10 20 days prior to infusion 1 lab work drawn at dr dahirs office or local pcp office when prearranged through beth, administrative assistant for dr. The doctor considers these changes statistically significant. Patients were randomized to receive a 15minute intravenous infusion of zoledronic acid 5 mg n 1,065 or placebo n 1,062 once yearly for up to 5 years. I have remained at the same level of clumsiness and low energy before and after the reclast.
You may eat normally before receiving your infusion. If above labs have not been done within last 30 days the infusion center will draw on day of infusion. Reclast zoledronic acid sometimes called zoledronate is a bisphosphonate medicine that alters bone formation and breakdown in the body. The infusion experience should be comfortable for you. Zoledronic acid injection is used to treat hypercalcemia high levels of calcium in the blood that may occur in patients with some types of cancer. Drink two 2 glasses of fluids, such as water, within a few hours before receiving reclast to help prevent kidney problems 3. Give with 1,200 mg calcium orally and 800 to 1,000 international units of vitamin d. This can slow bone loss and may help prevent bone fractures. Final thoughts there are a number of situations in which reclast should not be taken, as well as several precautions and warnings people should be aware of before starting the medication. Talk to your doctor if you have any questions about reclast. Reclast is used to treat or prevent osteoporosis caused by menopause, steroid use, or gonadal failure. Zoledronic acid injection should be reinitiated at the same dose as that prior to treatment interruption. Common side effects include fever, joint pain, high blood pressure, diarrhea, and.
However, it is possible that not all of the warnings or precautions were discussed in this article. A single dose of reclast zoledronic acid injection should not exceed 5 mg and the duration of infusion should. Reclast zoledronate is a good choice for osteoporosis if you arent able to take bisphosphonates by mouth. Now that your doctor has prescribed an infusion therapy, you may have several questions about what to expect. The maximum recommended dose of zoledronic acid injection in. Jul 24, 2016 compared to the baseline in 2009 and this year 2016, there has been an 8. Retreatment of pagets disease after a single treatment with reclast in pagets disease an extended remission period is observed. Obtain peripheral iv access give sodium chloride 0. Decision to repeat infusion this year made on basis of the significant improvement seen on this years.
Bone is a living tissue constantly being remodeled. Sterile, nonpyrogenic, preservativefree, dehpfree, pvcfree. Reclast is the brand name of the prescription drug zoledronic acid, used to treat and prevent osteoporosis a condition in which bones become weak and may break easily it may also be used to. The ph of the reclast solution for infusion is approximately 6. Zolendronic acid is used to treat or prevent osteoporosis. Stomatitis, a condition with painful swelling and sores inside the mouth. You have to go to your doctors office or an infusion center to get each dose by iv infusion. Consider coadministering 1g paracetamol, as this tends to lessen the severity of acute phase reaction. The maximum recommended zoledronic acid dose for the treatment of bone metastases is. Reclast zoledronic acid dose, indications, adverse. Zolendronic acid is given as an infusion through a vein in your arm lasting 15 minutes. Onceyearly zoledronic acid in the prevention of osteoporotic. Zoledronic acid intravenous route description and brand.
This medication guide does not take the place of talking with your doctor about your medical condition or treatment. I was told to drink plenty of water the day of and the days following as this helps protect the kidneys. Zoledronic acid reclast for osteoporosis steps american. Reclast zoledronic acid is a bisphosphonate used to treat pagets disease, high blood levels of calcium caused by cancer hypercalcemia of malignancy, multiple myeloma a type of bone marrow cancer or cancer that has spread from elsewhere in the body to the bone, to treat or prevent osteoporosis in postmenopausal women, and to increase bone mass in men with. Reclast drug interactions can occur if it is combined with nsaids and diuretics, among other things. Makes it extra scary when i take a header into the floor, too. Geneva woods nurse to educate patient andor caregiver regarding possible adverse events related to the therapy and iv access device. Will you have infusion site extravasation with reclast. Common and rare side effects for reclast intravenous. Medication guide reclast reclast zoledronic acid injection. My osteoporosis is pretty bad, and i have already tried everything else. Administering zoledronic acid to patients with bone metastases. Last year was advised reclast could cause ugly side effects.
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